Gatifloxacin is identified as important antibacterial agent of class Quinolone antibiotic, acting by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. Clinical studies show that cationic preparations forms complexes with quinolone antibiotics and decrease their absorption to various extents. The objective of this study was to investigate the effect of calcium on oral absorption of gatifloxacin in rats to establish a preclinical food supplement-drug interaction model. Gatifloxacin (400 mg) and Calcium supplement (containing 250 mg calcium) used for the study. The peak plasma concentration i.e. Cmax after administration of gatifloxacin was 5.1667 µg/ml at 3.0 hr (Tmax). The Cmax and Tmax of gatifloxacin administered along with calcium supplement were 3.4119 µg/ml and 3.0 hr, respectively. The relative bioavailability of the gatifloxacin tablet administered along with calcium supplement was 66.04% in comparison with gatifloxacin tablet which is assumed to 100%. This reduction in gatifloxacin bioavailability suggests that calcium may forms complex with gatifloxacin leads to the decrease in bioavailability. This food supplement-drug interaction rat model may be useful in prediction of potential food-drug interactions in humans, and also can be utilized as a preclinical tool for interaction study.
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